The effect on kidney function after liver transplantation can be extrapolated from the kidney transplant study. A study examined the safety of cannabis in 1,225. Due to the significant lack of data on the safety and efficacy of cannabis use in liver transplant recipients and their outcomes, a general recommendation cannot be made at this time. In the periods before and after liver transplantation, patient survival appeared to be the same for both users and non-users, according to a small group of data (28.2). A study examined the safety of cannabis in 1225 kidney transplant recipients and reported similar survival and kidney graft function one year after the transplant (30).
The safety of cannabis in a patient with a liver transplant was confirmed in a case report (3). Another study found no negative impact on liver function) (3.CBD can raise liver enzyme levels). And this could indicate liver damage. In most cases, this occurs with very high doses of CBD or when taken with certain medications.
However, more research is needed to understand why this occurs. As for the effect of CBD oil on the kidneys, the jury is still out. There is some evidence that CBD oil may be harmful to the kidneys, but there is also evidence that it could help kidney function. Most CBD and THC are excreted through the faeces and, therefore, there is usually no need to adjust the dose of CBD in people with chronic kidney disease.
However, scientists and doctors aren't sure exactly how CBD affects the kidneys, so caution is recommended for people with kidney disease. While generally considered safe, CBD can cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth and, in rare cases, liver damage. Taking CBD with other medications that have similar side effects may increase the risk of developing unwanted symptoms or toxicity. In other words, taking CBD at the same time as over-the-counter or prescription drugs and substances that cause drowsiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol, can cause increased sleepiness, fatigue, and possibly accidental falls and accidents while driving.
You can also experience increased sedation and tiredness when consuming certain herbal supplements, such as kava, melatonin and St. Taking CBD with stimulants (such as Adderall) may cause a decrease in appetite, while taking it with metformin, a medication for diabetes, or with certain medications for heartburn (such as Prilosec), it may increase the risk of diarrhea.